- Epilepsy and Seizures:
- Devinsky, O., Cross, J. H., Laux, L., Marsh, E., Miller, I., Nabbout, R., … & Wright, S. (2017). Trial of cannabidiol for drug-resistant seizures in the Dravet syndrome. New England Journal of Medicine, 376(21), 2011-2020. https://core.ac.uk/reader/132155047?utm_source=linkout
- Thiele, E. A., Marsh, E. D., French, J. A., Mazurkiewicz-Beldzinska, M., Benbadis, S. R., Joshi, C., … & Sommerville, K. (2018). Cannabidiol in patients with seizures associated with Lennox-Gastaut syndrome (GWPCARE4): a randomised, double-blind, placebo-controlled phase 3 trial. The Lancet, 391(10125), 1085-1096. https://pubmed.ncbi.nlm.nih.gov/29395273/
- Anxiety and Stress:
- Crippa, J. A., Derenusson, G. N., Ferrari, T. B., Wichert-Ana, L., Duran, F. L., Martin-Santos, R., … & Hallak, J. E. (2011). Neural basis of anxiolytic effects of cannabidiol (CBD) in generalized social anxiety disorder: a preliminary report. Journal of Psychopharmacology, 25(1), 121-130. https://pubmed.ncbi.nlm.nih.gov/20829306/
- Blessing, E. M., Steenkamp, M. M., Manzanares, J., & Marmar, C. R. (2015). Cannabidiol as a potential treatment for anxiety disorders. Neurotherapeutics, 12(4), 825-836. https://link.springer.com/content/pdf/10.1007/s13311-015-0387-1.pdf
- Chronic Pain:
- Lynch, M. E., & Campbell, F. (2011). Cannabinoids for treatment of chronic non-cancer pain; a systematic review of randomized trials. British Journal of Clinical Pharmacology, 72(5), 735-744. https://bpspubs.onlinelibrary.wiley.com/doi/pdf/10.1111/j.1365-2125.2011.03970.x
- Boehnke, K. F., Scott, J. R., Litinas, E., Sisley, S., Williams, D. A., & Clauw, D. J. (2016). Pills to pot: observational analyses of cannabis substitution among medical cannabis users with chronic pain. The Journal of Pain, 17(6), 739-749. https://pubmed.ncbi.nlm.nih.gov/30690169/
- Inflammatory Conditions:
- Nagarkatti, P., Pandey, R., Rieder, S. A., Hegde, V. L., & Nagarkatti, M. (2009). Cannabinoids as novel anti-inflammatory drugs. Future Medicinal Chemistry, 1(7), 1333-1349. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2828614/
- Booz, G. W. (2011). Cannabidiol as an emergent therapeutic strategy for lessening the impact of inflammation on oxidative stress. Free Radical Biology and Medicine, 51(5), 1054-1061. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3085542/
- CBD and Managing Pain and Inflammation:
- Baron, E. P. (2018). Medicinal Properties of Cannabinoids, Terpenes, and Flavonoids in Cannabis, and Benefits in Migraine, Headache, and Pain: An Update on Current Evidence and Cannabis Science. Headache: The Journal of Head and Face Pain, 58(7), 1139-1186. doi:10.1111/head.13345. https://accurateclinic.com/wp-content/uploads/2020/05/Medicinal-Properties-of-Cannabinoids-Terpenes-and-Flavonoids-in-Cannabis-and-Benefits-in-Migraine-Headache-and-Pain-An-Update-on-Current-Evidence-and-Cannabis-Science-2018-1.pdf
- Vučković, S., Srebro, D., Vujović, K. S., Vučetić, Č., & Prostran, M. (2018). Cannabinoids and Pain: New Insights From Old Molecules. Frontiers in Pharmacology, 9, 1259. doi:10.3389/fphar.2018.01259. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277878/
- Hammell, D. C., Zhang, L. P., Ma, F., Abshire, S. M., McIlwrath, S. L., Stinchcomb, A. L., & Westlund, K. N. (2016). Transdermal cannabidiol reduces inflammation and pain-related behaviours in a rat model of arthritis. European Journal of Pain, 20(6), 936-948. doi:10.1002/ejp.818. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4851925/
- Philpott, H. T., O’Brien, M., & McDougall, J. J. (2017). Attenuation of early phase inflammation by cannabidiol prevents pain and nerve damage in rat osteoarthritis. Pain, 158(12), 2442-2451. doi:10.1097/j.pain.0000000000001052. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5690292/
- Xiong, W., Cui, T., Cheng, K., Yang, F., Chen, S. R., Willenbring, D., … & Zhang, L. (2012). Cannabinoids suppress inflammatory and neuropathic pain by targeting α3 glycine receptors. Journal of Experimental Medicine, 209(6), 1121-1134. doi:10.1084/jem.20120242. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3371734/
- Nagarkatti, P., Pandey, R., Rieder, S. A., Hegde, V. L., & Nagarkatti, M. (2009). Cannabinoids as novel anti-inflammatory drugs. Future Medicinal Chemistry, 1(7), 1333-1349. doi:10.4155/fmc.09.93. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2828614/
- Fitzcharles, M. A., Baerwald, C., Ablin, J., & Häuser, W. (2016). Efficacy, tolerability, and safety of cannabinoid treatments in the rheumatic diseases: A systematic review of randomized controlled trials. Arthritis Care & Research, 68(5), 681-688. doi:10.1002/acr.22727. https://pubmed.ncbi.nlm.nih.gov/26767993/
- CBD’s Anti-Tumoral and Anti-Cancer Properties:
- Shrivastava A, Kuzontkoski PM, Groopman JE, Prasad A. Cannabidiol induces programmed cell death in breast cancer cells by coordinating the cross-talk between apoptosis and autophagy. Mol Cancer Ther. 2011 Jul;10(7):1161-72. doi: 10.1158/1535-7163. https://aacrjournals.org/mct/article/10/7/1161/91099/Cannabidiol-Induces-Programmed-Cell-Death-in
- Seltzer ES, Watters AK, MacKenzie D Jr, Granat LM, Zhang D. Cannabidiol (CBD) as a Promising Anti-Cancer Drug. Cancers (Basel). 2020 Oct 30;12(11):3203. doi: 10.3390/cancers12113203. https://pubmed.ncbi.nlm.nih.gov/33143283/
- Marcu JP, Christian RT, Lau D, Zielinski AJ, Horowitz MP, Lee J, Pakdel A, Allison J, Limbad C, Moore DH, Yount GL, Desprez PY, McAllister SD. Cannabidiol enhances the inhibitory effects of delta9-tetrahydrocannabinol on human glioblastoma cell proliferation and survival. Mol Cancer Ther. 2010 Jan;9(1):180-9. doi: 10.1158/1535-7163.MCT-09-0407. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2806496/
- Fisher T, Golan H, Schiby G, PriChen S, Smoum R, Moshe I, Peshes-Yaloz N, Castiel A, Waldman D, Gallily R, Mechoulam R, Toren A. In vitro and in vivo efficacy of non-psychoactive cannabidiol in neuroblastoma. Curr Oncol. 2016 Mar;23(2):S15-22. doi: 10.3747/co.23.2893. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4791143/
- Lukhele ST, Motadi LR. Cannabidiol rather than Cannabis sativa extracts inhibit cell growth and induce apoptosis in cervical cancer cells. BMC Complement Altern Med. 2016 Sep 1;16(1):335. doi: 10.1186/s12906-016-1280-0. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5009497/
- Solinas M, Massi P, Cantelmo AR, Cattaneo MG, Cammarota R, Bartolini D, Cinquina V, Valenti M, Vicentini LM, Noonan DM, Albini A, Parolaro D. Cannabidiol inhibits angiogenesis by multiple mechanisms. Br J Pharmacol. 2012 Nov;167(6):1218-31. doi: 10.1111/j.1476-5381.2012.02050.x. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3504989/
